There is provided herein the antibody of specific binding IL1RAP.Invention further describes can encode the related polynucleotides of provided IL1RAP specific antibodies or antigen-binding fragment, express the cell of provided antibody or antigen-binding fragment and the antibody or antigen-binding fragment of relevant carriers and detectable label.In addition, also describing the method for using provided antibody.For example, the antibody provided can be used for diagnosing, treat or monitor the progress, recession or stability of IL1RAP expression type cancers;For determining whether cancer patient should receive treatment;Or for determining whether subject suffers from IL1RAP expression type cancers, and therefore may be adapted to be treated for the multi-specificity antibody of IL1RAP and CD3 as described herein with IL1RAP specific anti-cancer therapeutic agents are all.
