The present invention provides compound of formula I or its officinal salt, tautomer or stereoisomer, wherein each variable is as defined herein. The present invention also provides the Pharmaceutical composition containing this kind of compound, the symptom of such as malaria of the disease as caused by plasmodium parasites and/or the method for disease are treated, prevent, inhibit, improve or eradicated using this kind of compound.本發明提供式I化合物或其可藥用鹽、互變異構體或立體異構體,其中各變量如本文中所定義。本發明還提供了含有這類化合物的藥用組合物、使用這類化合物來治療、預防、抑制、改善或根除由瘧原蟲寄生蟲引起的疾病如瘧疾的病狀和/或症候的方法。