HARRISON, BRYCE A.,KIMBALL, DAVID S.,MABON, ROSS,RAWLINS, DAVID B.,GOODWIN, NICOLE CATHLEEN
申请号：
ES10194063
公开号：
ES2477216T3
申请日:
2007.09.27
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula: or a pharmaceutically acceptable salt thereof, wherein: A is aryl, cycloalkyl or heterocycle； B is aryl, cycloalkyl or heterocycle； Y is O, S, SO, SO2, NR4, (C (R5) 2) p, (C (R5) 2) qC (O) - (C (R5) 2) q, (C (R5) 2) qC (O) O- (C (R5) 2) q, (C (R5) 2) q- OC (O) - (C (R5) 2) q, (C (R5) 2) qC (O) NR4- (C (R5) 2) q, (C (R5) 2) q-NR4C (O) - (C (R5) 2) q, or (C (R5) 2) q-NR4C (O) NR4- (C (R5) 2) q； R1 is OR1A, SR1A, SOR1A, SO2R1A, or R1A； each R1A is independently hydrogen, alkyl, aryl or heterocycle； R2 is fluorine or OR2A； each of R2A, R2B and R2C is independently hydrogen, alkyl, C (O) alkyl, C (O) aryl or aryl； R3 is hydrogen, alkyl, aryl or heterocycle； each R4 is hydrogen or alkyl； each R5 is independently hydrogen, hydroxyl, halogen, amino, cyano, OR5A, SR5A, or alkyl； each R5A is independently alkyl； Each R6 is independently hydrogen, hydroxyl, halogen, amino, cyano, nitro, CCR6A, OR6A, SR6A, SOR6A, SO2R6A, C (O) R6A, CO2R6A, CO2H, CON (R6A) (R6A), CONH (R6A), CONH2 , NHC (O) R6A, NHSO2R6A, alkyl, aryl or heterocycle； each R6A is alkyl, aryl or heterocycle； Each R7 is hydrogen, hydroxyl, halogen, amino, cyano, nitro, CCR7A, OR7A, SR7A, SOR7A, SO2R7A, C (O) R7A, CO2R7A, CO2H, CON (R7A) (R7A), CONH (R7A), CONH2, NHC (O) R7A, NHSO2R7A, alkyl, aryl or heterocycle； each R7A is independently alkyl, aryl or heterocycle； m is 1 to 3； n is 1 to 3； p is 0 to 3, and each q is independently 0 to 2, in which the term "alkyl" refers to a linear, branched and / or cyclic chain hydrocarbon having 1 to 20 carbon atoms； the term "alkyl" it includes saturated hydrocarbons in addition to alkenyl and alkynyl fractions, the term "alkenyl" refers to a linear, branched and / or cyclic hydrocarbon having 2 to 20 carbon atoms, and which includes at least one carbon-carbon double bond； and the term "alkynyl" refers to a linear, branched and / or cyclic chain hydrocarbon having 2 to 20 carbon atoms, and which includes at least one carbon-carbon triple bond.Compuesto de f
