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Novel benzimidazole derivatives as EP4 antagonists
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
PETERS, Olaf,BRÄUER, Nico,BLUME, Thorsten,TER LAAK, Antonius,ZORN, Ludwig,NAGEL, Jens,KAULFUSS, Stefan,LANGER, Gernot,KUHNKE, Joachim
申请号:
ES13798684
公开号:
ES2637738T3
申请日:
2013.12.03
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of the general formula (I) ** (See formula) ** wherein R1a, R1b independently represent each other, H, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C6 cycloalkyl - (CH2) m, heterocycle C3-C6- (CH2) n, C1-C5 alkoxy-C1-C3 alkyl, C3-C6 cycloalkoxy-C1-C3 alkyl, amino-C1-C3 alkyl, C1-C5 alkyl-amino- C1-C3 alkyl, C1-C5 dialkyl-C1-C3 amino-alkyl or cyano, wherein the optionally existing heterocyclic unit is preferably selected from the group consisting of oxetane, tetrahydrofuran, tetrahydropyran, 1,4-dioxane, morpholine, azetidine, pyrrolidine, piperazine and piperidine and wherein the optionally existing alkyl, cycloalkyl or heterocycloalkyl radicals may be mono- or polysubstituted, the same or different with halogen, C1-C5 alkyl, hydroxy, carboxy, C1-C5 alkyl, C1- alkoxy C5-carbonyl-C1-C5 alkyl or C1-C5-alkyl sulfonyl, R4 represents H, F, Cl, C1-C2 alkyl, C3-C5 cycloalkyl, C1-C2 alkoxy or C3-C4-mecycloalkyl lime, wherein the corresponding alkyl or cycloalkyl unit may be mono- or polysubstituted, the same or different, with halogen or hydroxy, A represents RO-CO (CH2) p, where R represents H or C1-C2 alkyl is 0 , 1, 2 or 3, n is 0, 1, 2 or 3, p is 0 and B is selected from the following structures, ** (See formula) ** R6 represents H, F, Cl, CH3, CF3 CH3O or CF3O, R7, R8 represent in each case, independently of each other, H, F, Cl, cyano, SF5, C1-C3 alkyl, C3-C5 cycloalkyl, C1-C2 alkoxy or C3-C4-methyl cycloalkyl, wherein the corresponding alkyl or cycloalkyl unit may be mono- or polyhalogenated, and R9 represents C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C6- (CH2) n cycloalkyl, C3-C6- (CH2) heterocycloalkyl n, or C1-C7 alkoxy-C2-C5 alkyl, wherein the optionally existing heterocyclic unit is selected from the group consisting of oxetane, tetrahydrofuran, tetrahydropyran, morpholine, pyrrolidine and piperidine and where the alq units optionally existing uyl, cycloalkyl or heterocycloalkyl may be mono- or polysubstituted, the same or different, with halogen,
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