BRITANOVA, OLGA VLADIMIROVNA,IZRAELSON, MARK ALEKSANDROVIC,LUKYANOV, SERGEY ANATOLIEVICH
申请号：
CA3086849
公开号：
CA3086849A1
申请日:
2018.12.25
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to monoclonal antibodies which specifically bind to the TRBV9 family of human T-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, to an expression vector, to a method for producing the antibody, and to the use of said antibody for treating diseases or disorders associated with the family of human T-cell receptors. The invention is directed towards producing antibodies which can be used for eliminating T-cells carrying T-cell receptors of the TRBV9 family, in particular for treating ankylosing spondylitis, coeliac disease and blood cancers, in the pathogenesis of which T-cell receptors of the TRBV9 family are involved.
