Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual.本發明提供癌症之治療,其係藉由在個體原發性腫瘤位置經定位投與高單一劑量或短期劑量處理;在一段足以激活抗腫瘤反應之時間後,從該個體收集T細胞;利用有效劑量之化療劑量治療該個體;及將該T細胞群再引入該個體內。