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Cyclic amine derivative and pharmaceutical use thereof
专利权人:
Toray Industries; Inc.
发明人:
Yasuhiro Morita,Naoki Izumimoto,Katsuhiko Iseki,Shunsuke Iwano,Shuji Udagawa,Tomoya Miyoshi,Yuji Osada,Tetsuro Koreeda,Masanori Murakami,Motohiro Shiraki,Kei Takahashi,Keiyu Oshida
申请号:
US15024185
公开号:
US09505740B2
申请日:
2014.09.26
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A compound exerts a strong analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The cyclic amine derivative is represented by formula, a prodrug thereof or a pharmacologically acceptable salt thereof:wherein A represents a group represented by Formula (IIa), (IIb) or (IIc):whereinR3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R4 represents a hydrogen atom or an alkylcarbonyl group having 2 to 6 carbon atoms or an alkyl group having 1 to 6 carbon atoms and optionally substituted with an alkylcarbonylamino group having 2 to 6 carbon atoms and n represents 1 or 2, in which when R3 and R4 each independently represent an alkyl group having 1 to 6 carbon atoms, R1 represents an alkyl group having 1 to 6 carbon atoms and substituted with a hydroxyl group, an amino group or a carboxyl group.
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