The present invention provides an agent for treatment and prevention of fracture and bone disease comprising carbon dioxide as an active ingredient, and a bone growth-enhancing agent comprising carbon dioxide is also provided. Further a synergic or additive effect of treatment and prevention of fracture and bone disease and bone growth-enhancement is also provided by combination of said agent for fracture treatment comprising carbon dioxide as an active ingredient and an inhibitor of bone absorption and/or an enhancer of bone formation.本發明提供一種以以二氧化碳為有效成分之骨折治療劑、骨成長促進劑或骨疾治療及預防劑，本發明進一步提供藉由上述以二氧化碳為有效成分之骨折治療劑與骨吸收抑制劑及/或骨形成促進劑併用，而可獲得對骨折及骨疾病之預防及治療，以及促進骨成長之相乘相加之功效。
