By the the present invention, and carbon dioxide as an active ingredient, and the prevention of fractures and bone disease and therapeutic agent, as well as bone growth promoting agent is provided. Furthermore the present invention, the said fracture treatment agent for carbon dioxide as an active ingredient, by combining a bone resorption inhibitor and / or a bone formation promoter, a bone fracture and prevention and treatment of bone diseases, as well as bone growth promoting synergistic or additive effect is I obtained.本発明により、二酸化炭素を有効成分とする、骨折及び骨疾患の予防・治療剤、並びに骨成長促進剤が提供される。さらに本発明により、二酸化炭素を有効成分とする当該骨折治療剤と、骨吸収抑制剤及び/もしくは骨形成促進剤とを組み合わせることにより、骨折及び骨疾患の予防と治療、並びに骨成長促進の相乗もしくは相加効果が得られる。
