The present invention relates to a kind of crystal forms of disulfate and preparation method thereof of jak kinase inhibitor. In particular it relates to (3aR,5s,6aS)-N- (methoxyl group -1 3-,2,4- thiadiazoles -5- bases) -5- (methyl (7H- pyrrolo-es [2,3-d] pyrimidine-4-yl) amino) hexahydro cyclopentano [c] pyrroles -2 (II types crystallization of 1H- formamide disulfates and preparation method thereof. The preparation method includes crystallizing any crystal form or unformed formula (I) compound solid in single organic solvent or their mixed organic solvents to obtain the II types crystallization of formula (I) compound. The II types crystallization of formula obtained by the present invention (I) compound has good stability of crystal form and chemical stability, and recrystallisation solvent low toxicity and low residue used, can preferably use what clinical treatment.本發明涉及一種JAK激酶抑制劑的硫酸氫鹽的結晶形式及其製備方法。具體地，本發明涉及(3aR,5s,6aS)-N-(3-甲氧基-1,2,4-噻二唑-5-基)-5-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)六氫環戊并[c]吡咯-2(1H-甲酰胺硫酸氫鹽的II型結晶及其製備方法。所述製備方法包括將任意晶型或無定型的式(I)化合物固體在單一的有機溶劑或者它們的混合有機溶劑中結晶得到式(I)化合物的II型結晶。本發明所得到式(I)化合物的II型結晶具備良好的晶型穩定性和化學穩定性，並且所用結晶溶劑低毒低殘留，可更好地用於臨床治療。
