The present invention relates to crystal form of bisulfate of JAK (Janus kinase) inhibitor and preparation method thereof. Specifically, The present invention relates to Form III crystal of (3aR,5s,6aS)-N-(3-methoxyl-1,2,4-thiadiazole-5-group)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-group)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-formamide bisulfate and a preparation method thereof. The Form III crystal of compound of formula (I) has good crystal stability, low toxicity and low residue of crystallization solvent, can be better used for clinical treatment.本發明涉及一種JAK激酶抑制劑的硫酸氫鹽的晶型及其製備方法。具體地,本發明涉及(3aR,5s,6aS)-N-(3-甲氧基-1,2,4-噻二唑-5-基)-5-(甲基(7H-吡咯並[2,3-d]嘧啶-4-基)胺基)六氫環戊並[c]吡咯-2(1H)-甲醯胺硫酸氫鹽的III晶型及其製備方法。本發明式(I)化合物的III晶型具備良好的晶型穩定性,並且所用結晶溶劑低毒低殘留,可更好地用於臨床治療。
