WINTERS, GEOFFREY C.,MANDEL, ALEXANDER L.,BOURQUE, ELYSE MARIE JOSEE,RICH, JAMES R.,HSIEH, TOM HAN HSIAO
申请号：
CA2935077
公开号：
CA2935077A1
申请日:
2014.12.29
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates. The conjugates have the formula of [(P)-(L)]m-(T), wherein (P) is a payload compound, (L) is a linker, (T) is a targeting moiety and m is an integer from 1- to 10. Also provided are pharmaceutical compositions comprising such conjugates and there use in treating cancer.
