SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES

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专利权人:

Zymeworks Inc.

发明人:

WINTERS, Geoffrey, C.,MANDEL, Alexander, L.,BOURQUE, Elyse, Marie, Josée,RICH, James, R.,HSIEH, Tom, Han, Hsiao

申请号：

EP14875148

公开号：

EP3086815A4

申请日:

2014.12.29

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates. The conjugates have the formula of [(P)-(L)]m-(T), wherein (P) is a payload compound, (L) is a linker, (T) is a targeting moiety and m is an integer from 1- to 10. Also provided are pharmaceutical compositions comprising such conjugates and there use in treating cancer.

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