SMITH, Peter Andrew,ROBERTS, Tucker Curran,HIGUCHI, Robert I.,PARASELLI, Prasuna,KOEHLER, Michael F. T.,SCHWARZ, Jacob Bradley,CRAWFORD, James John,LY, Cuong Q.,HANAN, Emily J.,HU, Huiyong,CHEN, Yongs
申请号：
PE2019001675
公开号：
PE20191618A1
申请日:
2018.02.22
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
The invention refers to a formula compound (I),Among them, R1 and R2 are h, C1-C6, CH2CH (OH) ch2nh2 and others, R3 and R5 are h or - (C1-C6) tar, R4 is H - (C1-C6) tar, - (C1-C6) tar, - (C1-C6) tar Oh, etc., or R3 and R4 are combined to form an isocyclic propyl ring, or R4 and R5 and the carbon atoms attached to form a ring； R6, R7 and R8 are independent h, fluorination and other types； R9 and R10 are h and - (C1-C6) asphalt, etc.； R11 and R12 are h, NH2 and other types, respectively； R11 and R18 are combined into an optional heterocyclic chemical ring； R12 is h； R15, R16, R17 and R18 are independent H,-(C1-C6) asphalt, among others； X may replace - (C1-C6) asphalt -.This is a link, or-YesAmong other things, Z is h, halogenated-nh2, etc.； R27 and R28 are independent halogenated, nitrated, hydroxyl, etc.； P and Q are 0-2； or a salt acceptable in pharmacology. These compounds are Senal cucumber inhibitors of class 1 bacteria (SPSB),A basic protein in bacteria is an effective way to treat bacterial infection, because the pathogens of these bacteria are resistant to a variety of drugs. He also mentioned composers who had these things in themLa presente invencion se refiere a un compuesto de formula (I), en donde R1 y R2 son cada uno independientemente H, alquilo C1-C6, -CH2CH(OH)CH2NH2, entre otros； R3 y R5 son H o - (C1-C6 ) alquilo； R4 es H, -(C1-C6) alquilo, -(C1-C6) alquilo-OH, entre otros； o R3 y R4 se combinan para formar un anillo heterocicloalquilo； o R4 y R5 y el atomo de carbono al que se encuentran unidos forman un anillo ciclopropilo； R6, R7 y R8 son cada uno independientemente H, fluor, entre otros； R9 y R10 son H, - (C1-C6) alquilo, entre otros； R11 y R12 son cada uno independientemente H, -NH2, entre otros； R11 y R18 se combinan para formar un anillo heterocicloalquilo opcionalmente sustituido y R12 es H； R15, R16, R17 y R18 son cada uno independientemente H, - (C1-C6) alquilo, entre otros； X es opcionalmente sustituido -(C1-C6) alquilo-, entre otros； Y
