LANTHORN, Thomas Herbert,SAVELIEVA, Katerina,ZAMBROWICZ, Brian
申请号：
ES13709722
公开号：
ES2657061T3
申请日:
2013.03.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
An inhibitor of adapter-associated kinase 1 activity (AAK1) for use in the treatment or management of fibromyalgia, wherein said inhibitor is a compound selected from the group consisting of: a) compounds of formula: ** Formula ** and pharmaceutically acceptable salts thereof, wherein: R1 is R1A or optionally substituted C1-12 hydrocarbyl or 2-12 membered heterocarbyl, the optional substitution of which is with one or more R1A； Each R1A is independently -OR1C, -N (R1C) 2, -C (O) R1C, -C (O) OR1C, -C (O) N (R1C) 2, -N (R1C) C (O) OR1C, optionally substituted C1-12 cyano, halo or hydrocarbyl or 2-12 membered heterocarbyl, whose optional substitution is with one or more R1B； each R1B is independently -OR1C, - -N (R1C) 2, -C (O) R1C, -C (O) OR1C, - C (O) N (R1C) 2, - N (R1C) C (O) OR1C , cyano or halo； each R1C is independently hydrogen or optionally substituted C1-12 hydrocarbyl or 2-12 membered heterocarbyl, whose optional substitution is with one or more cyano, halo or hydroxyl； R2 is -NR2AR2B, wherein R2A is hydrogen and R2B is optionally substituted C1-12 hydrocarbyl or 2-12 membered heterocarbyl, the optional substitution of which is with one or more R2C； or R2A and R2B are taken together to form a 4-7 membered heterocycle optionally substituted with one or more R2C； Each R2C is independently -OR2D, -N (R2D) 2, -C (O) R2D, -C (O) OR2D, -C (O) N (R2D) 2, -N (R2D) C (O) OR2D, optionally substituted C1-12 cyano, halo or hydrocarbyl or 2-12 membered heterocarbyl, whose optional substitution is with one or more R2D； each R2D is independently hydrogen or optionally substituted C1-12 hydrocarbyl or 2-12 membered heterocarbyl, whose optional substitution is with one or more cyano, halo or hydroxyl； and R3 is hydrogen or C1-6 alkyl optionally substituted with one or more cyano, halo or hydroxyl； b) compounds of formula: ** Formula ** and pharmaceutically acceptable salts thereof, wherein: R1 is R1A or optionally substituted C1-12 hydrocarbyl or 2-12 membered heterocarbyl,
