Provided are diphenyl sulfide derivatives which have excellent S1P3 antagonistic activity and are useful as drugs. Intensive studies have been made for the purpose of creating a compound having S1P3 antagonistic activity. As a result of the intensive studies, it has been found that diphenyl sulfide derivatives representedby general formula (1) have excellent S1P3 antagonistic activity. In general formula (1), R1 is a hydrogen atom or the like； R2 is an optionally substituted alkyl group having 1 to 6 carbon atoms, or the like； X is a methylene group which may be substituted with one or two fluorine atoms, or the like； Y is a hydrogen atom or the like； and Z is a halogen atom.
