BALKAN, BORK,HUGHES, THOMAS EDWARD,HOLMES, DAVID GRENVILLE,VILLHAUER, EDWIN BERNARD
申请号：
CA2673615
公开号：
CA2673615C
申请日:
2001.01.19
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to a combination which comprises a DPP-IV inhibitor which is (S)-1-[(3-hydroxy-1--adamantyl)amino]acetyl-2-cyano-pyrrolidine, in free form or in acid addition salt form, and metformin or a pharmaceutically acceptable salt thereof for simultaneous, separate or sequential use in the prevention, delay of progression or treatment of conditions mediated by dipeptidylpeptidase-IV (DPP-IV), in particular diabetes, more especially type 2 diabetes mellitus, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, metabolic acidosis, ketosis, arthritis, obesity and osteoporosis； and the use of such combination for the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight.
