Ezio Bonvini;Ling Huang;Leslie S. Johnson;Bhaswati Barat
发明人:
Ezio Bonvini,Bhaswati Barat,Ling Huang,Leslie S. Johnson
申请号：
US14118516
公开号：
US09376495B2
申请日:
2012.05.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.
