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MUTANT INTERLEUKIN-2 POLYPEPTIDES
专利权人:
ROCHE GLYCART AG
发明人:
AST, OLIVER,BRUENKER, PETER,FREIMOSER-GRUNDSCHOBER, ANNE,HERTER, SYLVIA,HOFER, THOMAS U.,HOSSE, RALF,KLEIN, CHRISTIAN,MOESSNER, EKKEHARD,NICOLINI, VALERIA G.,UMANA, PABLO
申请号:
SG2013060207
公开号:
SG192673A1
申请日:
2012.02.07
申请国别(地区):
SG
年份:
2013
代理人:
摘要:
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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