Ast, Oliver,Bruenker, Peter,Freimoser-Grundschober, Anne,Herter, Sylvia,Hofer, Thomas U.,Hosse, Ralf,Klein, Christian,Moessner, Ekkehard,Nicolini, Valeria G.,Umana, Pablo
申请号：
AU2012215573
公开号：
AU2012215573B2
申请日:
2012.02.07
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
