AST, OLIVER,BRUENKER, PETER,FREIMOSER-GRUNDSCHOBER, ANNE,HERTER, SYLVIA,HOFER, THOMAS U.,HOSSE, RALF,KLEIN, CHRISTIAN,MOESSNER, EKKEHARD,NICOLINI, VALERIA G.,UMANA, PABLO
申请号：
TW101103928
公开号：
TW201237165A
申请日:
2012.02.07
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the &agr； -subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
