PURPOSE: A transformed animal which reveals a preS1 W4P variation protein of a hepatitis B virus and a use thereof are provided to valuably use for investigation of pathogenesis of a liver disorder which is sex-specific as a liver-disordered animal model and to valuably use a liver disease medicine for screening. CONSTITUTION: A non-human transformed animal which has been through transformation with an HBV dielectric contains a W4P preS1 gene to reveal a W4P preS1 variation protein of hepatitis B virus (HBV). A dielectric HBV dielectric is an A type or a C type. The HBV dielectric has a base sequence from 1433 to 4674 among the base sequence of a sequence number 1. The HBV dielectric has a base sequence from 1448 to 4694 among the base sequence of a sequence number 2. The transformed non-human animal is a liver disease model which reveals over-expression of an HBs antigen and an HBe antigen protein.HBV의 W4P preS1 변이 단백질을 발현하는 형질전환 동물 모델이 제시되어 있다. 상기 형질전환 동물 모델은 웅성특이적으로 HBs 항원과 HBe 항원 단백질이 과발현하고 간조직에 염증이 유발된 비인간 동물로서, 본 발명의 형질전환 동물 모델을 사용하여, 성별 특이적인 간질환의 발병 기전을 연구하거나 간질환 치료제를 스크리닝할 수 있다.
