BRUCE ALEXANDRA MARSHALL,GROSCHE PHILIPP,GUIMARAES CARLA,KANTER AARON,LOU CHANGGANG,USERA AIMEE RICHARDSON,YASOSHIMA KAYO,YUAN JUN,ZECRI FREDERIC,ZHAO HONGJUAN
申请号：
IN201617003908
公开号：
IN201617003908A
申请日:
2016.02.03
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The invention provides a cyclic polypeptide of Formula I : I or an amide an ester or a salt thereof or a bioconjugate thereof wherein X1 X3 X4 X7 X8 X9 X10 X11 X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF) chronic heart failure pulmonary hypertension atrial fibrillation Brugada syndrome ventricular tachycardia atherosclerosis hypertension restenosis ischemic cardiovascular diseases cardiomyopathy cardiac fibrosis arrhythmia water retention diabetes (including gestational diabetes) obesity peripheral arterial disease cerebrovascular accidents transient ischemic attacks traumatic brain injuries amyotrophic lateral sclerosis burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
