GOLOSOV, ANDREI,GROSCHE, PHILIPP,HU, QI-YING,IMASE, HIDETOMO,PARKER, DAVID THOMAS,YASOSHIMA, KAYO,ZECRI, FREDERIC,ZHAO, HONGJUAN
申请号：
CA2862240
公开号：
CA2862240A1
申请日:
2013.01.25
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention provides a synthetic polypeptide of Formula 1': or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
