Medical devicescomprising an interventional componentfor delivering multiple beneficialagents in which a hydration inhibitorcontrols release of at least one beneficialagent from the device. The hydrationinhibitor is relatively less hydrophilicthan the beneficial agent and preferablyis a drug. Suitable beneficial agentsinclude (I) dexamethasone, estradiol,anti-proliferative agents, anti-plateletagents, anti-inflammatory agents,anti-thrombotic agents, cytotoxic drugs.agents that inhibit cytokine or chemokinebinding, cell de-differentiationinhibitors, anti-lipaedemic agents,matrix metalloproteinase inhibitors,cytostatic drugs, or combinationsof these drugs, radiopaque markers.beta-carotene, tocopherols, tocotrienols,
