Loading of hydrophobic drugs into hydrophilic polymer delivery systems

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专利权人:

发明人:

申请号：

EP12178874.9

公开号：

EP2520287A1

申请日:

2007.02.09

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.

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