The invention relates to non-solvated crystals A, B and C of N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxy)-1-naphthamide and preparation methods thereof. The invention also relates to pharmaceutical compositions containing the crystals, and a use of the crystals in preparation of a medicament for the treatment of a disease associated with abnormal protein kinase activity or abnormal histone deacetylase activity.本發明涉及N-(2-氨基苯基)-6-(7-甲氧基喹啉-4-氧)-1-萘醯胺的非溶劑化晶體A、B、C及其製備方法。本發明還涉及含有所述晶體的藥物組合物，以及所述晶體在製備用於治療與蛋白激酶活性異常或組蛋白去乙醯化酶活性異常相關的疾病的藥物中的應用。
