FURET, PASCAL,GROTZFELD, ROBERT MARTIN,JONES, DARRYL BRYNLEY,MANLEY, PAUL,MARZINZIK, ANDREAS,PELLE, XAVIER FRANCOIS ANDRE,SALEM, BAHAA,SCHOEPFER, JOSEPH,JAHNKE, WOLFGANG
申请号：
CA2871715
公开号：
CA2871715A1
申请日:
2013.05.09
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention capable of inhibiting the tyrosine kinase enzymatic activity of the Abelson protein (ABL1), the Abelson- related protein (ABL2) and related chimeric proteins, in particular BCR-ABL1. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
