Furet, Pascal,Grotzfeld, Robert Martin,Jones, Darryl Brynley,Manley, Paul,Marzinzik, Andreas,Pelle, Xavier Francois Andre,Salem, Bahaa,Schoepfer, Joseph,Jahnke, Wolfgang
申请号：
AU2013261130
公开号：
AU2013261130A1
申请日:
2013.05.09
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention； capable of inhibiting the tyrosine kinase enzymatic activity of the Abelson protein (ABL1), the Abelson- related protein (ABL2) and related chimeric proteins, in particular BCR-ABL1. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
