The present invention provides compounds and a pharmaceutical composition for inhibiting an RNA virus causing a viral disease in a mammalian subject, the c pharmaceutical composition comprising at least two of a cholesterol-lowering compound, a methyltransferase inhibitor, a viral enzyme inhibitor, an SAHH (s-adenosylhomocysteine hydrolase) inhibitor and a DOTH inhibitor, wherein the effect of the at least two compounds synergistically inhibits the RNA virus.