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ANTICORPS MONOCLONAUX
专利权人:
VET THERAPEUTICS; INC.
发明人:
HANSEN, GENEVIEVE
申请号:
EP09811845
公开号:
EP2331579A4
申请日:
2009.09.04
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The invention provides heterochimeric antibodies and/or fragments thereof comprising (i) hypervariable region sequences wholly or substantially corresponding to sequences found in antibodies from a donor species; (ii) constant region sequences wholly or substantially corresponding to sequences found in antibodies from a target species which is different from the donor species; and (iii) heavy and/or light chain variable framework sequences which contain at least three non-CDR residues corresponding to sequences found in antibodies from a target species and at least three contiguous non-CDR residues corresponding to sequences found in antibodies from a donor species. The invention further provides antibody to canine or feline or equine antigens, e.g., CD20 or CD52, and methods of making and using antibodies as described.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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