MOORE, STEPHEN JAMES,NGUYEN, MARGARET THY LUU,HOSTETTER, DANIEL R.,VASILJEVA, OLGA,FLANDEZ, JEANNE GRACE
申请号：
CA2925106
公开号：
CA2925106A1
申请日:
2014.09.25
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.
