МУР, Стефен, Джеймс (US),НГУЕН, Маргарет, Тхи Луу (US),ХОСТЕТТЕР, Дэниел, Р. (US),ВАСИЛЬЕВА, Ольга (US),ФЛАНДЕС, Жан, Грейс (US)
申请号：
RU2016115542
公开号：
RU2016115542A
申请日:
2014.09.25
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.
