A linkage of mould opening and closing and bottom mould locking is provided in the invention. The linkage comprises a mould opening and closing assembly and a driving assembly. The mould opening and closing assembly comprises a liftable bottom mould, a fixed mould plate disposed on the machine frame of the bottle blowing machine, and a moving mould plate cooperating with the fixed mould plate. The linkage also comprises a bottom mould locking assembly for locking the bottom mould when the bottom mould rises. The bottom mould locking assembly comprises a rotation member, a swing member connected with the rotation member in transmission way, and a sliding block connected with the swing member in transmission way. The swing member is rotatable relative to the machine frame around a first axis, and the sliding block is slidably disposed on the machine frame. The driving assembly comprises a rotation shaft rotatable around a second axis, and a power source for driving the rotation shaft to rotate. The moving mould