An injection appliance (100) for injecting a substance into an organism (1) isdescribed, comprising a guide device (10) with a lumen (11) in which an injectiontool (21) is arranged in a displaceable manner, a displacement device (20) towhich the injection tool (21) is connected, and a holder device (30) that formsa support for the guide and displacement devices (10, 20), said guide and displacementdevices (10, 20) being arranged displaceably on the holder device (30). A methodfor injecting a substance into an organism (1) is also described.