FORMULATION FOR INDUCING BROADLY REACTIVE NEUTRALIZING ANTI-HIV ANTIBODIES

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专利权人:

DUKE UNIVERSITY

发明人:

ALAM, S., MUNIR,HAYNES, BARTON, F.,SEKARAN, MOSES, D.,TOMARAS, GEORGIA,SHEN, XIAOYING

申请号：

EP10759166

公开号：

EP2413951A4

申请日:

2010.04.05

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.

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