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Amino nicotinic and isonicotinic acid derivatives as DHODH inhibitors
专利权人:
Almirall; S.A.
发明人:
Castro Palomino Laria, Julio Cesar,Erra Sola, Montserrat,Navarro Romero, Eloisa,Lozoya Toribio, Maria Estrella
申请号:
AU2007338321
公开号:
AU2007338321B2
申请日:
2007.12.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
A compound of formula (I) wherein : - one of the groups Grepresentsa nitrogen atom or a group CR and the other represents a group CR;- G represents a nitrogen atom or a group CR; - Rrepresents a group selected from hydrogen atoms, halogen atoms, Calkyl groups which may be optionally substituted by 1, 2 or 3 substituents selectedfrom halogen atoms and hydroxy groups, and C cycloalkyl groupswhich may be optionally substituted by 1, 2 or 3 substituents selected from halogenatoms and hydroxy groups; - R represents a group selected from hydrogenatoms, halogen atoms, hydroxyl groups, C alkyl groups which maybe optionally substituted by 1, 2 or 3 substituents selected from halogen atomsand hydroxy groups, C alkoxy groups which may be optionally substitutedby 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and Ccycloalkyl groups which may be optionally substituted by 1, 2 or 3 substituentsselected from halogen atoms and hydroxy groups; - R, Rand R independently represent groups selected from hydrogen atoms,halogen atoms, Calkyl groups which may be optionally substitutedby 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and Calkoxy groups which may be optionally substituted by 1, 2 or 3 substituentsselected from halogen atoms and hydroxy groups; - Rrepresents a groupselected from hydrogen atoms, halogen atoms, hydroxyl groups, Calkyl groups which may be optionally substituted by 1, 2 or 3 substituents selectedfrom halogen atoms and hydroxy groups, and Calkoxy groups whichmay be optionally substituted by 1, 2 or 3 substituents selected from halogenatoms and hydroxy groups, and Ccycloalkoxy groups which may beoptionally substituted by 1, 2 or 3 substituents selected from halogen atomsand hydroxy groups; - one of the groups G and G is a nitrogenatom and the other is a CH group; - M is a hydrogen atom or an pharmaceutically acceptable
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