The University of North Carolina at Charlotte;The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人:
Bruce Allen Shapiro,Kirill Andreevich Afonin,Eckart H.U. Bindewald,Mathias D. Viard,Wojciech Kasprzak,Marina A. Dobrovolskaia,Justin R. Halman
申请号：
US16500765
公开号：
US20200199587A1
申请日:
2018.04.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The description provides a molecular switch comprising at least two nanoparticles, wherein a first nanoparticle comprises DNA and/or RNA oligonucleotides, and a second nanoparticle which is complementary to the first nanoparticle comprises reverse complementary DNA and/or RNA oligonucleotides of the first nanoparticle； wherein the complementary nanoparticles interact under physiological conditions leading to thermodynamically driven conformational changes in the first and second nanoparticles leading to their re-association to release one or more duplexes comprising said DNA and/or RNA oligonucleotides and the reverse complementary DNA and/or RNA oligonucleotides, and wherein the nanoparticles are not rings and have no single stranded toeholds.
