경북대학교 산학협력단;KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
BAEK, Moon-Chang,백문창,IM, Eun-Ju,임은주
申请号：
KRKR2019/009359
公开号：
WO2020/027509A1
申请日:
2019.07.26
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a composition for treating cancer and inhibiting metastasis, comprising a sulfonamide derivative as an active ingredient. More specifically, the composition comprising a sulfonamide derivative as an active ingredient can be provided as a cancer treatment agent and a metastasis inhibitor, as a sulfonamide derivative, from which an antibiotic susceptibility effect is completely removed, effectively inhibits secretion of exosomes by cancer cells and, thereby, shows excellent effects for inhibiting cancer cell multiplication and migration and is confirmed to be not cytotoxic to normal cells.La présente invention concerne une composition de traitement ou de prévention du cancer et d'inhibition de la métastase, comprenant un dérivé de sulfonamide en tant que principe actif. Plus spécifiquement, la composition comprenant un dérivé de sulfonamide en tant que principe actif peut être fournie en tant qu'agent de traitement du cancer et inhibiteur de la métastase, étant donné qu'un dérivé de sulfonamide, duquel un effet de sensibilité aux antibiotiques est complètement éliminé, inhibe efficacement la sécrétion d'exosomes par des cellules cancéreuses, présentant ainsi d'excellents effets d'inhibition de la multiplication et de la migration des cellules cancéreuses, et n'est pas cytotoxique pour les cellules normales.본 발명은 설폰아마이드 유도체를 유효성분으로 함유하는 암질환 치료 및 암전이 억제용 조성물에 관한 것으로, 보다 상세하게 항생제 감수성 효과가 완전히 제거된 설폰아마이드의 유도체가 암세포의 엑소좀 분비를 효과적으로 억제함으로써, 우수한 암세포의 증식 억제 및 이동능 억제효과를 나타내었으며, 정상세포에 대한 세포독성이 나타나지 않는 것이 확인됨에 따라, 상기 설폰아마이드 유도체를 유효성분으로 함유하는 조성물은 암질환 치료제 및 암전이 억제제로 제공될 수 있다.
