UTILISATION D'UNE COMPOSITION COMPRENANT DES EXOSOMES DÉRIVÉS DE CELLULES SOUCHES EN TANT QUE PRINCIPE ACTIF POUR LE RENFORCEMENT ET L'AMÉLIORATION FONCTIONNELLE DE LA BARRIÈRE CUTANÉE
A composition for strengthening skin barrier or improving skin barrier function according to the present invention is able to improve objective indicators related to the protection of skin barrier, the strengthening of skin barrier, and/or the improvement of skin barrier function. The composition according to the present invention is able to improve the indicator of loss of moisture in stratum corneum, for example, transepidermal water loss (TEWL), and increase skin hydration. In addition, the composition according to the present invention exhibits the effects of increasing the amount of ceramides, dihydroceramides and sphingoid bases, increasing the activities of enzymes that are involved in the synthesis thereof, and decreasing the activities of enzymes that are involved in the degradation thereof. Further, the composition according to the present invention is able to restore skin barrier function by reducing TSLP, IL-4, and IL-13 which are closely associated with skin barrier damage, and thus interrupting a vicious circle in which the lipids and proteins contributing to skin barrier decrease.
