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Attenuated swine influenza vaccines and methods of making the use thereof
- 专利权人:
- Inc.;Merial
- 发明人:
- HAUSE, Benjamin M.
- 申请号：
- AU2016202693
- 公开号：
- AU2016202693A1
- 申请日:
- 2016.04.27
- 申请国别(地区):
- AU
- 年份:
- 2016
- 代理人:
- 摘要：
- #$%^&*AU2016202693A120160519.pdf#####ABSTRACT This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of 5 production and use thereof. The attenuated strains are engineered to encode HA proteins having additional glycosylation sites, relative to the HA proteins encoded by the corresponding virulent parental viruses. Advantageously, the attenuated strains may be administered.Hyperglycosylation Growth Study. Lines represent mutants with additional engineered N-linked glycosylation sites 8 7 6 -0-1 o5 -0-2 4 -3-4 2 -.- 5 1 0 1 2 3 4 5 6 Rescued virus additional glycosylation sites (n) 0 RG parent (10-0036-2) 0 1 S71N 1 2 S71N, K90N 2 3 S71N, K90N, L173T 3 4 S71N, K90N, L173T, P287T 4 5 S71N, K90N, L173T, P287T, K294T 5 FIG. 3 Sheet (2/3)
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
