This invention has disclosed the manner which the solid-state product produces: The said manner water insolubility and/or makes the alkaline medicine active ingredient of water poor solubility dissolve, in the acidic solution which includes the acidification medicine obtains the acidic liquid which includes the glaze It is something which the alkalization medicine, mixes the acidic liquid which includes the adjuvant and the above-mentioned glaze, uniformly, does wet type corning modulo Here, the above-mentioned alkalization medicine is the reagent which makes the alkalization medicine and acidity of the mixed liquid of the acidic liquid decrease which includes the glaze vis-a-vis the acidity of the acidic liquid which includes the glaze. This invention discloses the solid-state product which is prepared and, by the above-mentioned manner. As for preparation manner of this invention environmental contamination, the problem in, machine comminution treating such as large attrition and risk with respect to serious safety is removed. As for manner of this invention, manipulation is simple, safety coefficient is high, is easy to apply to the production of industrialization. As for the solid-state product which is prepared by this manner dissolved property is good in comparison with those which are produced until recently by technology on that is possible to compare with technology until recently or at least there is an equal stability and a content uniformity.< Choice figure >It is not本発明は、固体調製物の製造する方法を開示しており:該方法は水不溶性及び/又は水難溶性のアルカリ性薬物活性成分を、酸性化剤を含んだ酸性溶液中に溶解させ、薬を含んだ酸性液体を得る;アルカリ化剤、アジュバント及び上述の薬を含んだ酸性液体を、均一に混ぜ、湿式造粒法を行うものであり;ここで、上述のアルカリ化剤は、薬を含んだ酸性液体の酸性に対して、アルカリ化剤と薬を含んだ酸性液体の混合液の酸性度を低減させる試薬である。本発明は又、上述の方法によって調製された固体調製物を開示する。本発明の調製方法は環境汚染、大きい損耗、重大な安全上のリスクなど、機械粉砕処理における問題を除去する。本発明の方法は、操作が簡便であり、安全係数は高く、工業化の生産に応用し易い。この方法によって調製された固体調製物は従来技術により生産されるものに比べて溶解特性がよく、そのうえ従来技術と比べてよいまたは少なくとも同等の安定性と含有量均一性がある。【選択図】なし
