Lindemann, Dirk, Prof. Dr.,Ho, Yu-Ping,Schnabel, Viktor
申请号：
EP20110186173
公开号：
EP2583974(B1)
申请日:
2011.10.21
申请国别(地区):
欧洲专利局
年份:
2017
代理人:
摘要：
The present invention relates to means and methods for pseudotyping of foamy viruses and the pharmaceutical application of pseudotyped foamy virus particles. The invention is applicable in biomedical research and in diagnostic and therapeutic applications. One aspect of the invention is a fusion protein comprising a foamy virus capsid (Gag) protein and a first dimerization domain that is applicable to dimerize with a second dimerization domain from another protein upon binding of a small molecule ligand to both the first and the second dimerization domain. Another aspect of the invention is a fusion protein comprising an envelope (Env) protein not derived from foamy virus and a second dimerization domain that is applicable to dimerize with a first dimerization domain from another protein upon binding of a small molecule ligand to both the first and the second dimerization domain. Another aspect of the invention is a fusion protein comprising a membrane-targeting domain not derived from foamy virus, and a sec
