VIRGILI-BERNADO, MARINA,ALONSO-XALMA, MONICA,ALEGRET-MOLINA, CARLOS,ALMANSA-ROSALES, CARMEN,MERCE-VIDAL, RAMON
申请号：
CA2949572
公开号：
CA2949572A1
申请日:
2015.06.02
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to compounds having dual pharmacological activity towards both the sigma (s) receptor, and the µ-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. (formula 1) wherein Y is (formula 2) or (formula 3) n is 1 or 2； q is 1, 2, 3, 4, 5 or 6； X is a bond, -C(O)O-, -C(0)NR 8-, -C(O)-, -0- or -C(R 4R 4.)-； R 1is C(0)R 5or S(O) 2R 5.
