ISAKSON PETER C,GHAYUR TARIQ,HARRIS MARIA C,SALFELD JOCHEN G,GU JIJIE,LIU JUNJIAN,MCPHERSON MICHAEL J
申请号：
NZ60010010
公开号：
NZ600100A
申请日:
2010.10.28
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
600100 Disclosed is a binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain； VD2 is a second variable domain； C is a constant domain； X1 is a linker； X2 is an Fc region； n is 0 or 1； wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding TNF, wherein the variable domains that form a functional target binding site for TNF comprise CDRs 1-3 from QVQLKESGPGLVAPSQSLSITCTVSGFSLTDYGVNWVRQPPGKGLEWLGMIWGDGSTDYDSTLKSRLSISKDNSKSQIFLKMNSLQTDDTARYYCAREWHHGPVAYWGQGTLVTVSA and CDRs 1-3 from DIVMTQSHKFMSTTVGDRVSITCKASQAVSSAVAWYQQKPGQSPKLLIYWASTRHTGVPD RFTGSGSVTDFTLTIHNLQAEDLALYYCQQHYSTPFTFGSGTKLEIKR.
