Centre National de la Recherche Scientifique (CNRS);Institut National de la Santé et de la Recherche Médicale (INSERM);Université Paris Descartes
发明人:
MEHRPOUR, Maryam,RODRIGUEZ, Raphael,HIENZSCH, Antje,TRANG, Mai,HAMAI, Ahmed
申请号：
ES15766107
公开号：
ES2755424T3
申请日:
2015.09.14
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
Compound of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diastereoisomers thereof: ** Formula ** in which: - W is selected from the group consisting of = O； -NR1R2； -NR3- (CH2) n-NR4R5； -O- (CH2) n-NR4R5； - NR3- (CH2) n-N + R6R7R8 and -O- (CH2) n-N + R6R7R8； - X is selected from the group consisting of = O, -OH； -NR1R2； -NR3- (CH2) n-NR4R5； -O- (CH2) n-NR4R5； -NR3- (CH2) n-N + R6R7R8 and -O- (CH2) n-N + R6R7R8, - Y is selected from the group consisting of -NR1R2； -NR3- (CH2) n-NR4R5； and -NR3- (CH2) n-N + R6R7R8, R1 and R2, identical or different, are selected from the group consisting of H； (C1-C16) alkyl； (C3-C16) alkenyl； (C3-C16) alkynyl； C3-C16 cycloalkyl； aryl； heteroaryl； (C1-C6) -alkyl-aryl； (C1-C6) -alkyl-heteroaryl； or R1 represents H and R2 represents OR9, where R9 is H, (C1-C6) alkyl, aryl and (C1-C6) alkyl-aryl； R3 is selected from the group consisting of H； C1-C6 alkyl； (C1-C6) -alkyl-aryl； R4 and R5, identical or different, are selected from the group consisting of H； (C1-C6) alkyl； aryl and (C1-C6) alkyl-aryl； R6, R7 and R8, identical or different, are selected from the group consisting of (C1-C6) alkyl； aryl and (C1-C6) alkyl-aryl； - Z is selected from the group consisting of OH； NHNR9R10； NHOC (O) R11； N (OH) -C (O) R11； OOH, SR12； 2-aminopyridine； 3-aminopyridine； -NR3- (CH2) n-NR4R5； and -NR3- (CH2) n-OH, in which: R9 and R10, identical or different, are selected from the group consisting of H, (C1-C6) alkyl, aryl and (C1-C6) alkyl - aryl； R11 is selected from the group consisting of H； (C1-C16) alkyl； (C3-C16) alkenyl； (C3-C16) alkynyl； aryl； heteroaryl； (C1-C6) -alkyl-aryl； (C1-C6) -alkyl-heteroaryl； R12 is selected from the group consisting of H； (C1-C16) alkyl； (C3-C16) alkenyl； (C3-C16) alkynyl； aryl； heteroaryl； (C1-C6) -alkyl-aryl； (C1-C6) -alkyl-heteroaryl, n = 0, 2, 3, 4, 5 or 6.Compuesto de fórmula (I), enantiómeros, mezcla de enantiómeros, diastereoisómeros y mezcla de diastereoisómeros del mismo:**
