The invention relates to hypophosphorous acid derivatives of formula (I) wherein —X is H or OH, —R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising -0-(CH2)n—COOH； —S—(CH2)n—COOH； —NH—(CH2)n—COOH； -0-(CH,R′)—COOH； —O—(CH2)n—OH； OR′, —R′ being a C1-C3 alkyl radical； —OH； —COOH； halogen, particularly —F, —CI, —Br, —I, —CF3； —OCF3； —N02； —CH═CH—COOH； —(CH2)n—COOH； O—(CH2)n—P03H2； O—(CF2)n—P03H2； O—(CH2)n—S03H； O—(CH2)n—CONHOH； O—(CH2)n-tetrazol； O—(CH2)n-hydroxyisoxazol—n=1 to 5, preferably 1-3； said hypophosrous acid derivatives being diastereoisomers or enantiomers.
