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Heteroaryloxy quinazoline derivative
专利权人:
MSD K.K.
发明人:
ASAI, MASANORI,IINO, TOMOHARU,SUGA, TAKUYA,OHNO, AKIO,OHTAKE, NORIKAZU
申请号:
ES08849029
公开号:
ES2493593T3
申请日:
2008.11.10
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound represented by the formula (I): wherein ring A represents a 5- or 6-membered heteroaryl ring that is selected from the group consisting of pyrazolyl, pyrazinyl, thiadiazolyl, thiazolyl, pyridinyl, thiatriazolyl, triazolyl, tetrazolyl groups, imidazolyl, pyrimidinyl, pyridazinyl, triazinyl, oxazolyl, oxadiazolyl and isoxazolyl, which may have one or two groups selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, halogen, hydroxy, C3-7 cycloalkyl and C1-6 alkyl having 1-3 different or identical C1-6 alkoxy groups, halogen atoms or hydroxy groups, or represents a ring in which the 5- or 6-membered heteroaryl ring and a becene or pyridine ring are condensed; Ring B represents a 5- or 6-membered heteroaryl group having 1-3 identical or different heteroatoms selected from the group consisting of nitrogen, sulfur and oxygen atoms; R represents a group selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, halogen, hydroxy and C1-6 alkyl, having 1-3 different or identical C1-6 alkoxy groups, halogen atoms or hydroxy groups; k represents an integer from 0 to 4; R1 indicates a group represented by a formula (II-1) in which R11 and R12 each independently represent hydrogen, C1-6 alkyl or C3-7 cycloalkyl, or R11 and R12 together with the nitrogen atom to which they are attached constitute aliphatic rings containing nitrogen, 4 to 7 members and which may be substituted with 1-3 identical or different halogen atoms, or any carbon atom of (CH2) m, together with R11 or R1225, may constitute aliphatic rings containing nitrogen, 4 to 7 members; any carbon atom of (CH2) m may be substituted with a C1-6 alkyl group; the nitrogen atom to which R11 and R12 are attached can form N-oxide; and m represents an integer from 2 to 6, a group represented by a formula (II-2)Un compuesto representado por la fórmula (I): en la que el anillo A representa un anillo heteroarilo de 5 o 6 miembros que se selecciona del grupo que consiste en grupos pirazolilo, pirazinilo, tia
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