Ltd.;Yafei Shanghai Biolog Medicine Science & Technolog Co.
发明人:
Chen LIU,Yuan LIU
申请号：
US15505861
公开号：
US20170266308A1
申请日:
2015.08.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided is an anticancer compound including a cleavable linker specifically activated in a tumor microenvironment, and use thereof. The anticancer compound is represented by the following formula, wherein, R1 is a normal functional group or a protection group； R2 is Ala, Thr, Val or Ile； R3 is Ala, Val or Asn； R4 is a drug group linked via a hydroxyl group or an amino group； and the general formula of the drug is R4H. The anticancer compound is only activated at a local portion of a tumor, thus avoiding the defect of immune system damage of a traditional chemotherapeutic drug, and promoting tumor immunization by removing a tumor immunosuppression cell. The anticancer compound or pharmaceutical composition thereof is jointly used with immunotherapy, thus improving the effect of treating the tumor, and effectively inhibiting tumor metastasis and osseous metastasis.
