LTD.;YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECHNOLOGY CO.
发明人:
LIU, CHEN,LIU, YUAN
申请号：
CA2958495
公开号：
CA2958495A1
申请日:
2015.08.21
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Provided are an anticancer compound comprising a fissionable linking group specifically activated in a tumor microenvironment, and use thereof. The anticancer compound is as represented by the following formula, wherein, R1 is a normal functional group or a protection group； R2 is Ala, Thr, Val or Tle； R3 is Ala, Val or Asn； R4 is a drug group linked via a hydroxyl group or an amino group； and the general formula of the drug is R4H. The anticancer compound is only activated at a local portion of a tumor, thus avoiding the defect of immune system damage of a traditional chemotherapeutic drug, and promoting tumor immunization by removing a tumor immunosuppression cell. The anticancer compound or pharmaceutical composition thereof is jointly used with immunotherapy, thus improving the effect of treating the tumor, and effectively inhibiting tumor metastasis and osseous metastasis.
